Whole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours
- Description:
- Uveal melanoma (UM) is the most common intraocular tumour in adults and despite surgical or radiation treatment of primary tumours, ~50% of patients progress to metastatic disease. Therapeutic options for metastatic UM are limited, with clinical trials having little impact. Here we perform whole-genome sequencing (WGS) of 103 UM from all sites of the uveal tract (choroid, ciliary body, iris). While most UM have low tumour mutation burden (TMB), two subsets with high TMB are seen; one driven by germline MBD4 mutation, and another by ultraviol...
- Display date:
- 2022
- Location:
- Wallis and Futuna Islands
- Format:
- journal article
- Collections:
- Australian National University Library
- Publisher:
- Macmillan Publishers Ltd
- Content partner:
- Australian National University Library
- Availability:
- Not specified
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